An engineering-procurement-construction (EPC) company based in Pennsylvania, USA, had won a project to provide all of the processes and CIP skid for a new biopharma plant being built in Luterbach, Switzerland, by Biogen-Idec.

A CIP skid is a module of machinery used for CIP (clean-in-place) processes. The project would have multiple bioreactors that needed their temperatures tightly controlled and regulated. This project also included flow meters, level sensors, and analysis instrumentation from Endress+Hauser.

Want to know more about Clean In Place, you can read the Visaya Article on CIP (clean-in-place) 

The team

The project team consisted of Biogen personnel from the home office in Denmark and the offices in Raleigh, North Carolina, and Allentown, Pennsylvania. It also had an engineering company from Cincinnati, Ohio.

After an initial presentation to a group of 22 people at Biogen’s Raleigh facility, Endress+Hauser worked with a Biogen project manager as a major point of contact. This manager also had several processes and project engineers responsible for the company’s engineering and selection of instrumentation for the project.

Easytemp TMR35 Compact hygienic thermometer

To know more about this product, you can check out the Visaya Product Review.  

BINOX PT100 Pt100 thermometer for hygenic application

The instrumentation

Biogen provided great support to its staff on the selection of the temperature instrumentation. The final scope of the project consisted of 1000+TMR35s, 250+TM411s, and 150+ TMT125s.

The company selected TM411 based on the following criteria:

– The process had stringent requirements for tight temperature control with wide excursions in range. Also, the temperature sensors on the bioreactors would need calibration at six-month intervals, while less critical temperature points only need annual calibration. The design of the TM411, with its QuickNeck design and ease of calibration without disrupting the process, played a large part in its selection.

– The company could provide all of the necessary documentation to confirm that the instruments conformed to the requirements of the ASME BPE regulations. 

– The company also provided a TSP, allowing the customer to use the Quick Disconnect feature of the TM411 with existing thermowells on the piping. A QuickNeck with a ½-inch NPT connected these thermowells.


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